NUP153

Across TCGA pan-cancer cohorts, NUP153 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NUP153’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NUP153 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NUP153 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where NUP153 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUP153 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.933	<.001	11	view →
THCA	All	II,III,IV	−0.886	<.001	9	view →
BLCA	Male	III,IV	+0.961	.001	7	view →
STAD	All	II,III,IV	+0.857	<.001	7	view →
LIHC	All	II,III,IV	+0.827	<.001	7	view →
KICH	Female	All	−1.281	<.001	6	view →
CHOL	All	All	+1.568	<.001	5	view →
LUSC	Male	II,III,IV	+0.633	<.001	5	view →
COAD	Male	All	+0.496	<.001	4	view →
BRCA	All	II,III,IV	+0.250	.004	4	view →
LUAD	Male	All	+0.459	.006	3	view →
KIRP	Female	II,III,IV	+0.714	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NUP153–HNSC

Open the HNSC breakdown →