NUDT8

Across TCGA patient cohorts, NUDT8 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT8-associated genes across cancer lineages are RNU6-718P, RBMY2NP, and SOCS5P1. Each is linked with NUDT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT8-to-partner and partner-to-NUDT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-718P grouped by NUDT8-low versus NUDT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT8→partner) and Y-score (partner→NUDT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-718P →	+0.214	+4.292	<.001	.006	3	2
LUAD	RBMY2NP →	+0.044	+7.930	<.001	.008	3	1
LUAD	SOCS5P1 →	+0.049	+7.930	<.001	.008	3	1
UCEC	MIR6857 →	+0.508	+3.621	<.001	.004	3	1
UCEC	LINC02348 →	+0.450	+3.041	.003	.005	3	1
UCEC	MIR6780B →	+0.588	+3.889	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

RNU6-718P by NUDT8 expression — UCEC

Explore this box plot interactively →