NUDT8

Across TCGA pan-cancer cohorts, NUDT8 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NUDT8 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NUDT8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUDT8 expression acts as an unfavorable survival marker, although some lineages such as STAD and LUSC show a favorable association.

ACC, BRCA, and STAD are the cancer types where NUDT8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	All	0.121	0.764	<.001	73	view →
BRCA	DFS	Tertile	III,IV	0.773	0.913	.002	66	view →
STAD	DFS	Tertile	II,III,IV	0.602	0.414	.001	61	view →
LUSC	DFS	Tertile	II,III,IV	0.506	0.276	<.001	46	view →
KIRP	DFS	Tertile	III,IV	0.892	0.167	.004	36	view →
ESCA	DFS	Tertile	II,III,IV	0.231	0.555	.001	34	view →
LAML	DFS	Tertile	All	0.320	0.599	.002	28	view →
COAD	DFS	Median	All	0.641	0.364	<.001	22	view →
CESC	DFS	Tertile	All	0.643	0.420	.002	20	view →
THYM	DFS	Quartile	All	1.000	0.587	.002	18	view →
MESO	OS	Median	II,III,IV	0.464	0.655	.025	17	view →
KICH	OS	Tertile	III,IV	0.290	0.894	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NUDT8–ACC (DFS)

Open the ACC breakdown →