NUDT18

Across TCGA patient cohorts, NUDT18 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT18-associated genes across cancer lineages are RNU6-1301P, GUSBP16, and TRMT112P1. Each is linked with NUDT18 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT18-to-partner and partner-to-NUDT18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1301P grouped by NUDT18-low versus NUDT18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT18→partner) and Y-score (partner→NUDT18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1301P →	+0.798	+3.663	<.001	<.001	3	2
UCEC	GUSBP16 →	+0.122	+2.863	<.001	.009	3	2
LUAD	TRMT112P1 →	+0.244	+7.930	<.001	.008	3	2
COAD	CEP19P1 →	+0.081	+4.251	<.001	.008	3	2
COAD	BCRP6 →	+0.115	+3.686	<.001	.005	3	1
SKCM	HDAC9-AS1 →	+0.203	+5.159	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

RNU6-1301P by NUDT18 expression — UCEC

Explore this box plot interactively →