NUDT16L1

Across TCGA patient cohorts, NUDT16L1 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible NUDT16L1-associated genes across cancer lineages are IGHVII-40-1, RNA5SP70, and MIR2392. Each is linked with NUDT16L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT16L1-to-partner and partner-to-NUDT16L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVII-40-1 grouped by NUDT16L1-low versus NUDT16L1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT16L1→partner) and Y-score (partner→NUDT16L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	IGHVII-40-1 →	+1.133	+5.064	<.001	.001	3	2
BRCA	RNA5SP70 →	+1.061	+7.731	<.001	.009	3	1
BRCA	MIR2392 →	+0.518	+8.471	<.001	.005	3	1
BRCA	RNA5SP98 →	+0.307	+7.731	<.001	.009	3	1
BRCA	RNU6-259P →	+0.379	+9.057	<.001	.003	3	1
UCEC	MOS →	+0.515	+3.517	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

IGHVII-40-1 by NUDT16L1 expression — BLCA

Explore this box plot interactively →