NUCKS1

Across TCGA patient cohorts, NUCKS1 mutation is significantly associated with the RNA expression of many other genes, with 1,266 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUCKS1-associated genes across cancer lineages are MIR6515, MIR6864, and NDUFA5P5. Each is linked with NUCKS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUCKS1-to-partner and partner-to-NUCKS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6515 grouped by NUCKS1-low versus NUCKS1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUCKS1→partner) and Y-score (partner→NUCKS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6515 →	+0.717	+8.055	<.001	.007	3	2
UCEC	MIR6864 →	+0.542	+2.101	.001	.003	3	2
UCEC	NDUFA5P5 →	+0.098	+2.912	.001	.009	3	2
UCEC	TUBB8P5 →	+0.327	+2.535	<.001	<.001	3	2
UCEC	CISTR →	+0.170	+2.042	.007	.004	3	2
UCEC	MYO19 →	+0.465	+3.346	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,266 associations by consensus.

MIR6515 by NUCKS1 expression — BRCA

Explore this box plot interactively →