NUCKS1

Across TCGA pan-cancer cohorts, NUCKS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NUCKS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NUCKS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NUCKS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where NUCKS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUCKS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.994	<.001	11	view →
LIHC	Female	II,III,IV	+1.187	<.001	9	view →
THCA	Male	All	−0.654	<.001	8	view →
KICH	Female	All	−1.311	<.001	7	view →
LUSC	All	All	+0.662	<.001	6	view →
BRCA	All	II,III,IV	+0.394	<.001	6	view →
CHOL	Male	All	+1.776	<.001	5	view →
LUAD	Male	All	+0.591	<.001	5	view →
KIRC	Male	III,IV	−0.315	.011	4	view →
BLCA	Female	III,IV	+0.634	.022	3	view →
UCEC	All	IV	−1.004	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NUCKS1–HNSC

Open the HNSC breakdown →