Q-omics provides the consensus-scored CISTR profile across patient tissues and cancer cell-line models. CISTR expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, CISTR is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, CISTR RNA expression shows 12,438 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRP, KICH, and THYM as cancer lineages where CISTR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CISTR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CISTR survival associations across molecular data types. CISTR RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CISTR RNA expression–survival associations across cancer types. High CISTR expression shows unfavorable associations in READ, ACC, LIHC and COAD, but favorable associations in KIRP and LGG. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for CISTR RNA expression.
This table summarizes CISTR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for CISTR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CISTR shows lower tumor expression in KICH, THCA, STAD, BRCA, COAD and LUAD. The KICH box plot shows higher CISTR RNA expression in normal versus tumor tissue (log2 FC = −0.265, t-test p < 0.001).
This table shows molecular features associated with CISTR in patient tissues and cancer cell lines. In patient samples, CISTR shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
