NT5DC4

Across TCGA patient cohorts, NT5DC4 mutation is significantly associated with the RNA expression of many other genes, with 220 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NT5DC4-associated genes across cancer lineages are RNU1-3, GIMAP1-GIMAP5, and SETD9. Each is linked with NT5DC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NT5DC4-to-partner and partner-to-NT5DC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-3 grouped by NT5DC4-low versus NT5DC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5DC4→partner) and Y-score (partner→NT5DC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-3 →	+0.393	+3.985	<.001	.001	3	2
LIHC	GIMAP1-GIMAP5 →	+0.024	+5.108	<.001	.008	3	1
UCEC	SETD9 →	+0.668	+3.475	.001	.002	3	1
UCEC	C1orf52 →	+0.435	+3.202	.005	.009	3	1
UCEC	MOCS2 →	+0.540	+3.218	.002	.009	3	1
UCEC	ADAL →	+0.712	+3.595	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 220 associations by consensus.

RNU1-3 by NT5DC4 expression — UCEC

Explore this box plot interactively →