NT5DC4

Across TCGA pan-cancer cohorts, NT5DC4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NT5DC4 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NT5DC4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NT5DC4 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

KIRC, ACC, and UVM are the cancer types where NT5DC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.544	0.691	<.001	82	view →
ACC	OS	Median	All	0.647	0.960	<.001	76	view →
UVM	DFS	Median	All	0.427	0.755	<.001	57	view →
BLCA	OS	Median	III,IV	0.488	0.206	<.001	56	view →
SKCM	OS	Median	All	0.398	0.279	<.001	55	view →
LGG	DFS	Median	All	0.668	0.794	<.001	53	view →
KIRP	OS	Tertile	All	0.544	0.816	.004	39	view →
OV	OS	Quartile	II,III,IV	0.411	0.280	.006	38	view →
MESO	OS	Median	All	0.300	0.463	.016	28	view →
DLBC	DFS	Median	II,III,IV	0.890	0.410	.006	26	view →
GBM	OS	Median	All	0.330	0.478	<.001	21	view →
COAD	DFS	Median	All	0.731	0.832	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NT5DC4–KIRC (DFS)

Open the KIRC breakdown →