NSUN6

Across TCGA cell cohorts, NSUN6 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NSUN6-associated genes across cancer lineages are H2BC1, H2AC1, and GAGE12F. Each is linked with NSUN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN6-to-partner and partner-to-NSUN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by NSUN6-low versus NSUN6-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN6→partner) and Y-score (partner→NSUN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
SOFT_TISSUE	GAGE12F →	+0.986	+4.635	<.001	.003	3	1
LUNG_SCLC	OR4A16 →	+0.023	+4.817	<.001	.001	3	1
LUNG_SCLC	C1orf146 →	+0.059	+4.044	.004	.009	3	1
LARGE_INTESTINE	MAS1 →	+0.002	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

H2BC1 by NSUN6 expression — SOFT_TISSUE

Explore this box plot interactively →