NSUN6

Across TCGA pan-cancer cohorts, NSUN6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NSUN6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NSUN6 RNA is repressed in tumor relative to normal tissue. In most cancer types NSUN6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, STAD, and COAD are the cancer types where NSUN6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NSUN6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.641	<.001	9	view →
STAD	Male	II,III,IV	+0.832	<.001	8	view →
COAD	Male	All	+0.697	<.001	8	view →
LUAD	Male	III,IV	+0.663	.004	7	view →
HNSC	All	III,IV	+0.407	.004	7	view →
KIRC	All	All	+0.227	<.001	7	view →
LUSC	All	II,III,IV	+0.509	<.001	6	view →
KICH	Female	All	−0.734	<.001	5	view →
CHOL	All	All	−0.850	<.001	3	view →
LIHC	All	All	−0.475	<.001	3	view →
READ	Female	All	+0.996	<.001	2	view →
KIRP	All	IV	+0.567	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NSUN6–THCA

Open the THCA breakdown →