NSUN5

Across TCGA patient cohorts, NSUN5 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSUN5-associated genes across cancer lineages are IRS1, GSK-3a-b_pS21_S9, and Tuberin_pT1462. Each is linked with NSUN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN5-to-partner and partner-to-NSUN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by NSUN5-low versus NSUN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN5→partner) and Y-score (partner→NSUN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	+0.234	+2.321	.024	.035	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.491	+3.459	.022	.005	3	1
UCEC	Tuberin_pT1462 →	+0.243	+2.321	.036	.035	3	1
UCEC	Caspase-8 →	-0.280	-2.973	.026	.035	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IRS1 by NSUN5 expression — UCEC

Explore this box plot interactively →