NSUN5

Across TCGA cell cohorts, NSUN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,954 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NSUN5-associated GO terms across cancer lineages are rRNA base methylation, Mitotic DNA replication, and Pre-mRNA catabolic process. Each is linked with NSUN5 in more than 11 cancer types. Because this analysis shows association rather than direction, both NSUN5-to-partner and partner-to-NSUN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA base methylation grouped by NSUN5-low versus NSUN5-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN5→partner) and Y-score (partner→NSUN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	rRNA base methylation →	+0.113	+0.657	<.001	<.001	3	12
SKIN	Mitotic DNA replication →	+0.156	+1.464	<.001	<.001	3	11
PANCREAS	Pre-mRNA catabolic process →	+0.134	+0.643	.001	.002	3	11
BLOOD_Lymphoma	Mitochondrial large ribosomal subunit assembly →	+0.141	+0.876	<.001	<.001	3	10
SKIN	Positive regulation of isotype switching to IgG isotypes →	+0.141	+1.200	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Signal transduction in response to DNA damage →	+0.091	+0.828	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,954 associations by consensus.

rRNA base methylation by NSUN5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →