NSUN5

Across TCGA cell cohorts, NSUN5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NSUN5-associated genes across cancer lineages are GSG1L2, LRIT2, and MEIKIN. Each is linked with NSUN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN5-to-partner and partner-to-NSUN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by NSUN5-low versus NSUN5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN5→partner) and Y-score (partner→NSUN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
SKIN	LRIT2 →	+0.029	+5.415	<.001	.004	3	1
SKIN	MEIKIN →	+0.019	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GSG1L2 by NSUN5 expression — LARGE_INTESTINE

Explore this box plot interactively →