NSDHL

Across TCGA patient cohorts, NSDHL mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSDHL-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with NSDHL in more than 1 cancer types. Because this analysis shows association rather than direction, both NSDHL-to-partner and partner-to-NSDHL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by NSDHL-low versus NSDHL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSDHL→partner) and Y-score (partner→NSDHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.528	+3.341	.010	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.597	+1.604	.010	.041	3	2
UCEC	EGFR_pY1068 →	-0.279	-3.584	.004	.002	3	1
UCEC	FoxM1 →	+0.247	+2.502	.015	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.132	-2.105	.006	.017	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Annexin-1 by NSDHL expression — UCEC

Explore this box plot interactively →