NSDHL

Across TCGA pan-cancer cohorts, NSDHL RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NSDHL’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NSDHL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NSDHL is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, KIRC, and LIHC are the cancer types where NSDHL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NSDHL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.452	<.001	11	view →
KIRC	Female	All	+0.550	<.001	11	view →
LIHC	Male	II,III,IV	+1.337	<.001	8	view →
BLCA	Male	All	+0.910	<.001	8	view →
HNSC	Male	All	+0.660	<.001	8	view →
READ	All	All	+1.063	.001	7	view →
LUSC	All	II,III,IV	+0.912	<.001	7	view →
LUAD	Female	II,III,IV	+0.464	<.001	7	view →
UCEC	All	III,IV	+0.606	.002	6	view →
BRCA	All	III,IV	+0.550	<.001	6	view →
STAD	All	All	+0.639	.003	3	view →
THCA	All	IV	−0.417	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NSDHL–COAD

Open the COAD breakdown →