NSDHL

Across TCGA pan-cancer cohorts, NSDHL RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NSDHL data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NSDHL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NSDHL expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

HNSC, KIRC, and SCLC are the cancer types where NSDHL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.624	0.751	.003	88	view →
KIRC	DFS	Quartile	All	0.679	0.379	<.001	60	view →
SCLC	OS	Median	II,III,IV	0.731	0.397	.001	60	view →
LIHC	OS	Median	All	0.712	0.837	<.001	54	view →
ACC	DFS	Median	All	0.212	0.719	.001	35	view →
PAAD	DFS	Quartile	All	0.389	0.676	<.001	23	view →
THCA	OS	Median	II,III,IV	1.000	0.760	.001	22	view →
SKCM	OS	Median	All	0.261	0.440	<.001	21	view →
KIRP	DFS	Tertile	All	0.842	0.954	.001	19	view →
UVM	DFS	Tertile	III,IV	0.561	1.000	.018	14	view →
UCEC	DFS	Median	IV	0.625	0.295	.027	10	view →
BRCA	OS	Median	III,IV	0.858	0.940	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NSDHL–HNSC (DFS)

Open the HNSC breakdown →