NSD2

Across TCGA cell cohorts, NSD2 mutation is significantly associated with the RNA expression of many other genes, with 975 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NSD2-associated genes across cancer lineages are NOP53, DPPA4, and FAM149A. Each is linked with NSD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSD2-to-partner and partner-to-NSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOP53 grouped by NSD2-low versus NSD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD2→partner) and Y-score (partner→NSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NOP53 →	+0.499	+2.523	.001	.003	3	2
BLOOD_Lymphoma	DPPA4 →	+0.481	+4.765	<.001	<.001	3	2
LARGE_INTESTINE	FAM149A →	+1.172	+3.541	<.001	<.001	3	2
LARGE_INTESTINE	TXNDC15 →	+0.511	+1.628	.002	.007	3	2
LARGE_INTESTINE	MAD2L2 →	+0.646	+1.628	.005	.007	3	2
LARGE_INTESTINE	ZNF428 →	+0.586	+2.043	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 975 associations by consensus.

NOP53 by NSD2 expression — LARGE_INTESTINE

Explore this box plot interactively →