NSD2

Across TCGA pan-cancer cohorts, NSD2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated NSD2 data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher NSD2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NSD2 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

MESO, UCS, and ACC are the cancer types where NSD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.260	0.509	<.001	132	view →
UCS	DFS	Quartile	II,III,IV	0.597	0.067	<.001	130	view →
ACC	OS	Median	All	0.344	0.855	<.001	110	view →
LIHC	DFS	Median	All	0.465	0.614	<.001	65	view →
KICH	OS	Quartile	II,III,IV	0.471	1.000	.002	61	view →
UVM	DFS	Quartile	II,III,IV	0.329	0.816	.003	49	view →
CESC	DFS	Quartile	All	0.419	0.698	.002	36	view →
SARC	OS	Median	All	0.394	0.763	<.001	32	view →
KIRP	DFS	Median	All	0.796	0.910	.003	30	view →
SKCM	DFS	Tertile	All	0.819	0.657	<.001	24	view →
THYM	OS	Median	II,III,IV	0.952	0.676	.002	19	view →
GBM	DFS	Tertile	All	0.388	0.176	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

NSD2–MESO (OS)

Open the MESO breakdown →