negative regulator of interferon responseGenealiases: lncCMPK2 · lncRNA-CMPK2
Q-omics provides the consensus-scored NRIR profile across patient tissues and cancer cell-line models. NRIR expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, NRIR is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, NRIR RNA expression shows 13,565 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight BLCA, HNSC, and UVM as cancer lineages where NRIR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NRIR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NRIR survival associations across molecular data types. NRIR RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NRIR RNA expression–survival associations across cancer types. High NRIR expression shows unfavorable associations in KIRC, LGG and UVM, but favorable associations in BLCA, SKCM and MESO. The BLCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify BLCA as the clearest survival context for NRIR RNA expression.
This table summarizes NRIR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for NRIR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NRIR shows lower tumor expression in KICH and LUSC and higher tumor expression in HNSC, KIRC, BLCA and STAD. The HNSC box plot shows higher NRIR RNA expression in tumor versus normal tissue (log2 FC = +0.551, t-test p < 0.001).
This table shows molecular features associated with NRIR in patient tissues and cancer cell lines. In patient samples, NRIR shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
