NRGN

Across TCGA patient cohorts, NRGN protein abundance is significantly associated with the RNA expression of many other genes, with 11,687 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NRGN-associated genes across cancer lineages are MEF2C, DPYSL2, and CNRIP1. Each is linked with NRGN in more than 5 cancer types. Because this analysis shows association rather than direction, both NRGN-to-partner and partner-to-NRGN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NRGN versus MEF2C in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRGN→partner) and Y-score (partner→NRGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MEF2C →	+0.822	+0.413	.002	<.001	3	6
BRCA	DPYSL2 →	+0.619	+0.432	.001	.003	3	6
HNSC	CNRIP1 →	+0.842	+0.574	<.001	<.001	3	6
BRCA	S1PR1 →	+0.824	+0.535	<.001	<.001	3	6
HNSC	SHROOM4 →	+0.630	+0.631	<.001	<.001	2	6
GBM	GPR85 →	+0.588	+0.756	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,687 associations by consensus.

NRGN vs MEF2C — HNSC

Explore this scatter interactively →