NRGN

Across TCGA pan-cancer cohorts, NRGN RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NRGN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NRGN RNA is repressed in tumor relative to normal tissue. In most cancer types NRGN is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and KIRP are the cancer types where NRGN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRGN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−2.812	<.001	11	view →
LUAD	Male	All	−3.123	<.001	9	view →
KIRP	Male	All	−1.891	<.001	9	view →
LUSC	Male	II,III,IV	−3.707	<.001	7	view →
LIHC	Female	II,III,IV	+1.186	<.001	7	view →
HNSC	All	All	+0.621	<.001	7	view →
UCEC	All	All	−1.811	<.001	6	view →
STAD	All	II,III,IV	+0.813	<.001	6	view →
THCA	All	All	+0.620	<.001	4	view →
BRCA	All	All	−0.261	.009	4	view →
CHOL	Male	All	+1.965	<.001	3	view →
ESCA	All	All	+1.421	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NRGN–KICH

Open the KICH breakdown →