NRGN

Across TCGA pan-cancer cohorts, NRGN RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NRGN data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NRGN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NRGN expression acts as an unfavorable survival marker, although some lineages such as UCEC and PAAD show a favorable association.

ACC, UVM, and UCEC are the cancer types where NRGN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.214	0.726	<.001	146	view →
UVM	OS	Median	All	0.415	0.774	<.001	87	view →
UCEC	DFS	Median	II,III,IV	0.716	0.380	.001	78	view →
PAAD	DFS	Median	II,III,IV	0.569	0.335	<.001	70	view →
MESO	OS	Median	All	0.418	0.666	<.001	66	view →
LAML	DFS	Quartile	All	0.175	0.530	<.001	36	view →
OV	OS	Tertile	III,IV	0.899	0.816	.008	30	view →
KICH	DFS	Tertile	II,III,IV	0.529	1.000	.017	28	view →
LIHC	OS	Quartile	All	0.690	0.880	.003	28	view →
BRCA	DFS	Quartile	II,III,IV	0.835	0.912	.003	27	view →
HNSC	OS	Median	All	0.629	0.778	.008	25	view →
LUSC	DFS	Quartile	All	0.651	0.791	.009	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NRGN–ACC (DFS)

Open the ACC breakdown →