NRGN

Across TCGA patient cohorts, NRGN mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRGN-associated genes across cancer lineages are RNA5SP414, MIR7702, and RPS29P32. Each is linked with NRGN in more than 1 cancer types. Because this analysis shows association rather than direction, both NRGN-to-partner and partner-to-NRGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by NRGN-low versus NRGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRGN→partner) and Y-score (partner→NRGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.724	+2.933	<.001	.006	3	1
UCEC	MIR7702 →	+0.415	+5.253	<.001	.001	3	1
UCEC	RPS29P32 →	+0.669	+3.277	<.001	.002	3	1
UCEC	MIR6784 →	+0.903	+3.553	.007	.003	3	1
UCEC	MIR6894 →	+0.753	+2.818	.001	.005	3	1
UCEC	RNA5SP502 →	+1.198	+3.315	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

RNA5SP414 by NRGN expression — UCEC

Explore this box plot interactively →