NRF1

Across TCGA patient cohorts, NRF1 mutation is significantly associated with the RNA expression of many other genes, with 3,402 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRF1-associated genes across cancer lineages are RN7SL248P, MTND6P11, and MIR4508. Each is linked with NRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRF1-to-partner and partner-to-NRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by NRF1-low versus NRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRF1→partner) and Y-score (partner→NRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.064	+3.137	<.001	<.001	3	3
LUSC	MTND6P11 →	+0.081	+5.578	<.001	.002	3	3
GBM	MIR4508 →	+0.657	+6.614	<.001	<.001	3	2
GBM	OR6P1 →	+0.069	+6.614	<.001	<.001	3	2
GBM	RNU6-246P →	+0.447	+4.969	<.001	.009	3	2
GBM	CENPIP1 →	+0.168	+5.857	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,402 associations by consensus.

RN7SL248P by NRF1 expression — UCEC

Explore this box plot interactively →