NRF1

Across TCGA pan-cancer cohorts, NRF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NRF1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NRF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NRF1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where NRF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.394	<.001	10	view →
LIHC	Female	II,III,IV	+1.059	<.001	9	view →
HNSC	Male	III,IV	+0.541	<.001	8	view →
KICH	Female	All	−0.979	<.001	7	view →
THCA	All	All	−0.265	<.001	7	view →
STAD	All	II,III,IV	+0.554	<.001	6	view →
CHOL	Male	All	+2.301	<.001	5	view →
UCEC	All	All	−0.572	<.001	4	view →
KIRC	All	All	+0.219	<.001	4	view →
ESCA	All	All	+0.677	<.001	3	view →
KIRP	All	IV	+0.700	.029	2	view →
READ	All	III,IV	+0.365	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NRF1–COAD

Open the COAD breakdown →