NR6A1

Across TCGA cell cohorts, NR6A1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR6A1-associated genes across cancer lineages are OR4K1, MS4A6E, and HSFY1. Each is linked with NR6A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR6A1-to-partner and partner-to-NR6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K1 grouped by NR6A1-low versus NR6A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR6A1→partner) and Y-score (partner→NR6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4K1 →	+0.022	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MS4A6E →	+0.044	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	HSFY1 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR6C75 →	+0.030	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	C16orf82 →	+0.013	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRTAP10-11 →	+0.018	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR4K1 by NR6A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →