NR6A1

Across TCGA pan-cancer cohorts, NR6A1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NR6A1 data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher NR6A1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NR6A1 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUAD show a favorable association.

UVM, UCEC, and ACC are the cancer types where NR6A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.855	0.396	<.001	108	view →
UCEC	DFS	Median	All	0.537	0.767	<.001	92	view →
ACC	DFS	Median	All	0.233	0.659	<.001	87	view →
LIHC	DFS	Median	All	0.463	0.620	<.001	85	view →
KICH	OS	Median	II,III,IV	0.629	0.959	.003	56	view →
UCS	DFS	Quartile	All	0.195	0.632	.005	38	view →
OV	OS	Tertile	All	0.789	0.887	.001	28	view →
BLCA	DFS	Tertile	IV	0.209	0.690	<.001	26	view →
LUAD	DFS	Quartile	II,III,IV	0.784	0.359	.003	26	view →
GBM	DFS	Tertile	All	0.466	0.223	.004	15	view →
SARC	OS	Tertile	All	0.360	0.615	.001	14	view →
SCLC	DFS	Tertile	All	0.590	0.291	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NR6A1–UVM (OS)

Open the UVM breakdown →