NR2C1

Across TCGA cell cohorts, NR2C1 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR2C1-associated genes across cancer lineages are PAGE4, LUZP4, and CGB2. Each is linked with NR2C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2C1-to-partner and partner-to-NR2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAGE4 grouped by NR2C1-low versus NR2C1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2C1→partner) and Y-score (partner→NR2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PAGE4 →	+1.125	+3.554	<.001	.007	3	1
BLOOD_Lymphoma	LUZP4 →	+0.055	+3.765	<.001	.001	3	1
BLOOD_Lymphoma	CGB2 →	+1.463	+3.584	.006	.007	3	1
BLOOD_Lymphoma	ZP4 →	+0.328	+3.321	.002	.006	3	1
BLOOD_Lymphoma	GNGT1 →	+0.282	+3.459	<.001	.004	3	1
BLOOD_Lymphoma	ASB11 →	+0.047	+3.765	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PAGE4 by NR2C1 expression — BLOOD_Lymphoma

Explore this box plot interactively →