NR2C1

Across TCGA pan-cancer cohorts, NR2C1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NR2C1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NR2C1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NR2C1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where NR2C1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NR2C1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.578	<.001	11	view →
THCA	Male	III,IV	−0.781	<.001	9	view →
LIHC	Male	All	+0.607	<.001	9	view →
STAD	Male	II,III,IV	+1.025	<.001	8	view →
COAD	All	II,III,IV	+0.633	<.001	7	view →
LUAD	Female	II,III,IV	−0.725	<.001	6	view →
BRCA	Female	All	−0.484	<.001	6	view →
ESCA	All	All	+1.215	.001	5	view →
KICH	Female	All	−1.106	<.001	5	view →
LUSC	All	All	−0.306	.001	5	view →
CHOL	Male	All	+1.275	<.001	4	view →
BLCA	Female	IV	+0.423	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NR2C1–HNSC

Open the HNSC breakdown →