NR1I2

Across TCGA cell cohorts, NR1I2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NR1I2-associated genes across cancer lineages are HBZ, TEX33, and PIGY. Each is linked with NR1I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1I2-to-partner and partner-to-NR1I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBZ grouped by NR1I2-low versus NR1I2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1I2→partner) and Y-score (partner→NR1I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HBZ →	+0.038	+3.257	.007	.001	3	2
LUNG_NSCLC_LUAD	TEX33 →	+0.018	+4.266	<.001	.004	3	2
BLOOD_Lymphoma	PIGY →	+1.948	+3.736	.002	.009	3	1
BLOOD_Leukemia	ZP2 →	+0.161	+4.409	<.001	.005	3	1
BLOOD_Leukemia	TRIM48 →	+0.151	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	ZIC3 →	+0.019	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

HBZ by NR1I2 expression — LARGE_INTESTINE

Explore this box plot interactively →