NR1I2

Across TCGA pan-cancer cohorts, NR1I2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NR1I2 data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NR1I2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NR1I2 expression acts as an unfavorable survival marker, although some lineages such as ACC and HNSC show a favorable association.

ACC, UCEC, and HNSC are the cancer types where NR1I2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	1.000	0.749	<.001	85	view →
UCEC	DFS	Tertile	All	0.551	0.694	<.001	80	view →
HNSC	DFS	Tertile	III,IV	0.708	0.534	.004	75	view →
LIHC	OS	Median	III,IV	0.773	0.429	.001	56	view →
KICH	DFS	Tertile	All	0.744	1.000	.001	47	view →
KIRC	OS	Tertile	All	0.519	0.692	.001	40	view →
LGG	DFS	Median	All	0.675	0.792	<.001	38	view →
READ	OS	Median	III,IV	0.768	0.325	.013	31	view →
MESO	OS	Median	II,III,IV	0.253	0.792	<.001	29	view →
UVM	OS	Quartile	II,III,IV	0.827	0.382	.016	26	view →
ESCA	OS	Median	All	0.617	1.000	.009	21	view →
SKCM	DFS	Tertile	All	0.271	0.139	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NR1I2–ACC (OS)

Open the ACC breakdown →