NR1H4

Across TCGA cell cohorts, NR1H4 mutation is significantly associated with the RNA expression of many other genes, with 236 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR1H4-associated genes across cancer lineages are TEX37, ASCL4, and C10orf71. Each is linked with NR1H4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1H4-to-partner and partner-to-NR1H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX37 grouped by NR1H4-low versus NR1H4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H4→partner) and Y-score (partner→NR1H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TEX37 →	+0.177	+3.700	<.001	.008	3	2
BONE	ASCL4 →	+0.016	+5.169	<.001	.004	3	1
SKIN	C10orf71 →	+0.004	+4.415	<.001	.007	3	1
SKIN	KCNK16 →	+0.068	+4.930	<.001	.001	3	1
OVARY	LECT2 →	+0.136	+3.473	<.001	.008	3	1
OVARY	SSX3 →	+0.072	+3.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 236 associations by consensus.

TEX37 by NR1H4 expression — OVARY

Explore this box plot interactively →