NR1H3

Across TCGA patient cohorts, NR1H3 mutation is significantly associated with the RNA expression of many other genes, with 4,155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1H3-associated genes across cancer lineages are RN7SL248P, CCNJP1, and RNU11-3P. Each is linked with NR1H3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1H3-to-partner and partner-to-NR1H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by NR1H3-low versus NR1H3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H3→partner) and Y-score (partner→NR1H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.060	+3.137	<.001	<.001	3	2
CESC	CCNJP1 →	+0.055	+4.669	<.001	.007	3	2
COAD	RNU11-3P →	+0.452	+3.918	<.001	<.001	3	2
HNSC	NENFP3 →	+0.160	+7.132	<.001	<.001	3	2
OV	TRAJ57 →	+0.699	+5.137	<.001	.007	3	2
SKCM	CDY3P →	+0.010	+4.408	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,155 associations by consensus.

RN7SL248P by NR1H3 expression — UCEC

Explore this box plot interactively →