NR1H3

Across TCGA pan-cancer cohorts, NR1H3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NR1H3 data layer compared with 6 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher NR1H3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NR1H3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, ACC, and LIHC are the cancer types where NR1H3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.849	0.711	<.001	135	view →
ACC	DFS	Median	All	0.214	0.683	<.001	101	view →
LIHC	OS	Tertile	All	0.572	0.770	<.001	71	view →
HNSC	DFS	Quartile	III,IV	0.406	0.168	<.001	65	view →
BLCA	OS	Median	All	0.760	0.655	.001	64	view →
BRCA	OS	Quartile	All	0.656	0.484	.001	43	view →
DLBC	OS	Quartile	III,IV	1.000	0.154	.017	24	view →
UVM	OS	Median	II,III,IV	0.687	0.940	.008	19	view →
KICH	DFS	Tertile	III,IV	0.221	0.859	.027	16	view →
SARC	OS	Quartile	All	0.930	0.759	.001	16	view →
UCEC	DFS	Median	All	0.729	0.544	.009	16	view →
GBM	OS	Quartile	All	0.213	0.574	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NR1H3–SKCM (OS)

Open the SKCM breakdown →