NR1D1

Across TCGA patient cohorts, NR1D1 mutation is significantly associated with the RNA expression of many other genes, with 629 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1D1-associated genes across cancer lineages are LETM1, TCF19, and LINC00628. Each is linked with NR1D1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NR1D1-to-partner and partner-to-NR1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LETM1 grouped by NR1D1-low versus NR1D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1D1→partner) and Y-score (partner→NR1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LETM1 →	+0.464	+2.545	.001	.001	3	3
UCEC	TCF19 →	+0.868	+3.711	<.001	<.001	3	3
UCEC	LINC00628 →	+0.197	+2.588	.006	<.001	3	2
UCEC	RNA5SP18 →	+0.658	+2.139	.001	.001	3	2
UCEC	TRGC2 →	+0.687	+2.513	<.001	.001	3	2
UCEC	WHAMM →	+0.604	+3.616	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 629 associations by consensus.

LETM1 by NR1D1 expression — UCEC

Explore this box plot interactively →