NR1D1

Across TCGA pan-cancer cohorts, NR1D1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NR1D1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NR1D1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NR1D1 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where NR1D1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NR1D1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+2.677	<.001	11	view →
COAD	All	IV	+1.664	<.001	11	view →
KIRC	Female	All	+1.041	<.001	11	view →
HNSC	All	All	+0.843	<.001	11	view →
KIRP	Female	II,III,IV	+1.640	<.001	10	view →
UCEC	All	II,III,IV	−1.410	<.001	6	view →
LUSC	All	II,III,IV	+1.318	<.001	6	view →
LUAD	Female	II,III,IV	+0.952	.001	6	view →
BRCA	Female	All	−0.603	<.001	6	view →
PAAD	All	All	+1.839	.029	4	view →
READ	All	All	+1.088	.007	4	view →
STAD	All	All	+0.715	.007	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NR1D1–THCA

Open the THCA breakdown →