NR1D1

Across TCGA pan-cancer cohorts, NR1D1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NR1D1 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NR1D1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NR1D1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SARC show a favorable association.

COAD, STAD, and UCEC are the cancer types where NR1D1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.430	0.698	<.001	77	view →
STAD	DFS	Median	II,III,IV	0.457	0.613	.003	49	view →
UCEC	DFS	Quartile	IV	0.908	0.280	.001	48	view →
ACC	DFS	Quartile	All	0.301	0.755	.001	27	view →
LUAD	OS	Quartile	All	0.749	0.878	.012	20	view →
GBM	DFS	Median	All	0.161	0.241	.013	19	view →
SARC	OS	Quartile	All	0.602	0.239	.003	18	view →
PAAD	OS	Median	II,III,IV	0.403	0.575	.012	15	view →
BLCA	OS	Quartile	IV	0.727	0.465	.006	15	view →
OV	OS	Median	III,IV	0.274	0.352	.014	12	view →
THCA	DFS	Median	All	0.782	0.883	.008	10	view →
MESO	OS	Median	IV	0.377	0.787	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NR1D1–COAD (DFS)

Open the COAD breakdown →