NR1D1

Across TCGA patient cohorts, NR1D1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1D1-associated genes across cancer lineages are eIF4E, ER-alpha_pS118, and MEK1. Each is linked with NR1D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1D1-to-partner and partner-to-NR1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NR1D1-low versus NR1D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1D1→partner) and Y-score (partner→NR1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.212	+3.013	.025	.018	3	1
UCEC	ER-alpha_pS118 →	-0.467	-3.807	.003	<.001	3	1
UCEC	MEK1 →	+0.492	+2.584	.002	.010	3	1
UCEC	MSH2 →	-0.442	-3.295	<.001	.009	3	1
UCEC	PDK1 →	+0.148	+2.820	.002	.035	3	1
UCEC	PRDX1 →	+0.320	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by NR1D1 expression — UCEC

Explore this box plot interactively →