NR1D1

Across TCGA cell cohorts, NR1D1 mutation is significantly associated with the RNA expression of many other genes, with 310 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR1D1-associated genes across cancer lineages are ODF1, FBXW10, and ACTR6. Each is linked with NR1D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1D1-to-partner and partner-to-NR1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF1 grouped by NR1D1-low versus NR1D1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1D1→partner) and Y-score (partner→NR1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ODF1 →	+0.048	+2.207	<.001	.008	3	2
LARGE_INTESTINE	FBXW10 →	+0.210	+3.491	<.001	.004	3	2
LARGE_INTESTINE	ACTR6 →	+0.557	+3.451	.006	.002	3	2
BLOOD_Leukemia	GLTP →	+0.603	+3.351	.004	.003	3	2
CNS	APCS →	+0.138	+4.643	.005	.003	3	1
OVARY	PPY →	+0.225	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 310 associations by consensus.

ODF1 by NR1D1 expression — BLOOD_Leukemia

Explore this box plot interactively →