NQO2

Across TCGA patient cohorts, NQO2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NQO2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and MEK1. Each is linked with NQO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NQO2-to-partner and partner-to-NQO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NQO2-low versus NQO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NQO2→partner) and Y-score (partner→NQO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.100	-2.973	.040	.035	3	1
UCEC	EGFR_pY1068 →	-0.263	-2.459	.030	.020	3	1
UCEC	MEK1 →	+0.402	+2.321	.023	.034	3	1
UCEC	Rad50 →	-0.411	-2.459	<.001	.020	3	1
UCEC	Annexin-1 →	+0.684	+3.189	.007	.010	3	1
UCEC	Shc_pY317 →	-0.198	-2.321	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

14-3-3_beta by NQO2 expression — UCEC

Explore this box plot interactively →