NQO2

Across TCGA cell cohorts, NQO2 protein abundance is significantly associated with the go_rna of many other GO terms, with 825 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NQO2-associated GO terms across cancer lineages are Dendritic cell differentiation, tRNA 3'-end processing, and Regulation of interleukin-23 production. Each is linked with NQO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NQO2-to-partner and partner-to-NQO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dendritic cell differentiation grouped by NQO2-low versus NQO2-high in BLOOD_Leukemia.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NQO2→partner) and Y-score (partner→NQO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Dendritic cell differentiation →	-0.219	-1.374	.006	<.001	3	4
SKIN	tRNA 3'-end processing →	+0.084	+1.017	.001	.002	3	4
LUNG_NSCLC_LUAD	Regulation of interleukin-23 production →	-0.176	-0.791	.001	.009	3	4
BLOOD_Leukemia	Proteasomal ubiquitin-independent protein catabolic process →	+0.117	+1.480	.003	.005	3	3
KIDNEY	Regulation of mRNA 3'-end processing →	-0.135	-1.177	.005	.009	3	3
KIDNEY	Peptide hormone processing →	-0.200	-1.177	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 825 associations by consensus.

Dendritic cell differentiation by NQO2 expression — BLOOD_Leukemia

Explore this box plot interactively →