NQO1

Across TCGA patient cohorts, NQO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,129 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NQO1-associated proteins across cancer lineages are TXNRD1, HTATIP2, and PIR. Each is linked with NQO1 in more than 6 cancer types. Because this analysis shows association rather than direction, both NQO1-to-partner and partner-to-NQO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NQO1 versus TXNRD1 in LSCC, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NQO1→partner) and Y-score (partner→NQO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TXNRD1 →	+0.911	+2.416	<.001	<.001	3	7
LSCC	HTATIP2 →	+0.561	+2.153	<.001	<.001	3	6
LSCC	PIR →	+0.808	+1.972	<.001	<.001	3	6
OV	RBM47 →	+0.552	+1.907	<.001	<.001	3	5
LSCC	CDH1 →	+0.575	+1.692	<.001	<.001	3	5
UCEC	IDH1 →	+0.560	+1.382	.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,129 associations by consensus.

NQO1 vs TXNRD1 — LSCC

Explore this scatter interactively →