NQO1

Across TCGA pan-cancer cohorts, NQO1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of NQO1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NQO1 RNA is repressed in tumor relative to normal tissue. In most cancer types NQO1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, LUAD, and LIHC are the cancer types where NQO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NQO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−2.070	<.001	10	view →
LUAD	Male	II,III,IV	+2.850	<.001	9	view →
LIHC	Male	II,III,IV	+4.625	<.001	8	view →
KIRP	Female	II,III,IV	+3.487	<.001	8	view →
COAD	Male	All	+1.513	<.001	7	view →
HNSC	All	II,III,IV	+0.824	.002	7	view →
LUSC	Male	All	+1.389	<.001	5	view →
KIRC	All	All	−0.273	.012	5	view →
PAAD	All	All	+3.142	.012	4	view →
UCEC	All	All	+1.385	.003	4	view →
BLCA	All	IV	+1.252	.013	4	view →
THCA	All	IV	−2.580	.011	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

NQO1–KICH

Open the KICH breakdown →