NQO1

Across TCGA pan-cancer cohorts, NQO1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NQO1 data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher NQO1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NQO1 expression acts as an unfavorable survival marker, although some lineages such as SARC and PRAD show a favorable association.

UVM, ACC, and UCS are the cancer types where NQO1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.410	0.879	<.001	139	view →
ACC	DFS	Median	All	0.411	0.740	<.001	84	view →
UCS	OS	Quartile	II,III,IV	0.224	0.922	<.001	72	view →
ESCA	DFS	Median	III,IV	0.299	0.561	.001	62	view →
HNSC	DFS	Quartile	All	0.500	0.688	<.001	49	view →
KIRP	DFS	Tertile	All	0.822	0.972	<.001	48	view →
LIHC	DFS	Median	All	0.468	0.634	<.001	39	view →
LGG	OS	Median	All	0.850	0.937	<.001	29	view →
GBM	DFS	Tertile	All	0.194	0.340	.004	27	view →
LUAD	OS	Quartile	III,IV	0.462	0.783	.008	22	view →
SARC	OS	Quartile	All	0.892	0.574	.001	17	view →
PRAD	DFS	Tertile	All	0.866	0.678	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NQO1–UVM (OS)

Open the UVM breakdown →