NQO1

Across TCGA patient cohorts, NQO1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NQO1-associated genes across cancer lineages are EGFR_pY1068, ERK2, and MSH2. Each is linked with NQO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NQO1-to-partner and partner-to-NQO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NQO1-low versus NQO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NQO1→partner) and Y-score (partner→NQO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.267	-2.459	.027	.020	3	1
UCEC	ERK2 →	+0.294	+3.321	.001	.010	3	1
UCEC	MSH2 →	-0.294	-3.160	.008	.019	3	1
UCEC	p62 Lck ligand →	+0.367	+2.459	.019	.020	3	1
UCEC	Shc_pY317 →	-0.237	-2.459	.001	.020	3	1
UCEC	VHL →	-1.353	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by NQO1 expression — UCEC

Explore this box plot interactively →