NQO1

Across TCGA cell cohorts, NQO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,933 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NQO1-associated GO terms across cancer lineages are Xenobiotic metabolic process, Ketone metabolic process, and Testosterone biosynthetic process. Each is linked with NQO1 in more than 11 cancer types. Because this analysis shows association rather than direction, both NQO1-to-partner and partner-to-NQO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Xenobiotic metabolic process grouped by NQO1-low versus NQO1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NQO1→partner) and Y-score (partner→NQO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Xenobiotic metabolic process →	+0.111	+4.357	.003	.002	3	12
LUNG_NSCLC_LUAD	Ketone metabolic process →	+0.098	+2.268	<.001	<.001	3	11
OVARY	Testosterone biosynthetic process →	+1.491	+1.746	<.001	.001	3	11
OESOPHAGUS	Terpenoid catabolic process →	+1.086	+1.458	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Glutathione biosynthetic process →	+0.306	+1.575	<.001	<.001	3	11
SOFT_TISSUE	Nitric oxide biosynthetic process →	+0.180	+2.803	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,933 associations by consensus.

Xenobiotic metabolic process by NQO1 expression — LIVER

Explore this box plot interactively →