NQO1

Across TCGA cell cohorts, NQO1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,473 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NQO1-associated genes across cancer lineages are FTL, OSGIN1, and G6PD. Each is linked with NQO1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NQO1-to-partner and partner-to-NQO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NQO1 versus FTL in LUNG_NSCLC_LUSC, with a Pearson correlation of 0.89.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NQO1→partner) and Y-score (partner→NQO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FTL →	+3.472	+3.952	.005	.007	3	6
BREAST	OSGIN1 →	+1.634	+2.066	.003	.002	3	6
BREAST	G6PD →	+1.883	+1.994	<.001	<.001	3	6
LUNG_NSCLC_LUSC	IQSEC2 →	+2.271	+2.659	<.001	.006	3	5
OESOPHAGUS	PGD →	+1.443	+2.081	<.001	.001	3	5
OESOPHAGUS	AKR1C3 →	+4.739	+2.834	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,473 associations by consensus.

NQO1 vs FTL — LUNG_NSCLC_LUSC

Explore this scatter interactively →