Across TCGA patient cohorts, NPY2R mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPY2R-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Cyclin-B1, and Src. Each is linked with NPY2R in more than 1 cancer types. Because this analysis shows association rather than direction, both NPY2R-to-partner and partner-to-NPY2R results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPY2R→partner) and Y-score (partner→NPY2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p38-MAPK_pT180_Y182 →	-0.413	-2.459	.011	.020	3	2
UCEC	Cyclin-B1 →	+0.586	+1.999	.001	.008	3	2
SKCM	Src →	-0.274	-1.874	.002	.049	3	2
UCEC	JNK2 →	+0.213	+2.142	<.001	.009	3	2
UCEC	TFRC →	+0.564	+2.906	.001	.001	3	2
UCEC	ATM →	-0.384	-2.700	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

NPY2R survival (RNA) · tumor vs normal (RNA) · all NPY2R data types